Liuzhong civilian king overcomes Yong Chenyong
Tumor cell is right of the medicaments that change cure be able to bear or endure the main obstacle that sufferring a gender is tumor cure. Clinical on a lot of tumour are in experienced after changing cure effectively at first, final still hard to avoid at having a relapse, its are main the reason is tumor cell suffer a gender to changing cure generation to be able to bear or endure. Accordingly, of changeover tumour cell be able to bear or endure property of a medicine, it is the key that raises tumor to change cure curative effect. Consider to make clear, the P- candy albumen that gene of tumor cell Mdrl codes (P-glycoprotein, the excessive expression of P-gp) is to bring about tumor cell much medicine to be able to bear or endure medicine (Multidrug Resistance, the main reason of MDR) [1] . At present a lot of medicaments can use the MDR of changeover tumour cell, but cannot from go up at all solve a problem, the effect owes beautiful, and have certain poisonous side effect [2] . With the tradition medication photograph comparing, gene therapy has effect distinctive, sensitive, poisonous side-effect is low and a lot of advantage, there is wide development perspective in MDR changeover.
Of 1.MDRl gene turn over justice few to get together deoxidization ribonucleic acid (AOD)
Li Huifang use complementary at MDRl gene the AOD of initiative place of transcribe of 5 ′ extreme turns after acquiring the KB-8-5 cell individual plant that conveys MDRl gene, the P-gp inside the cell conveys a level to drop, soft erythromycin chroma rises inside the cell, be turned to catch a cell the LC50 to medicaments by original medicaments of sensitive individual plant 5.6 times fall for 3.2 times. Changeover of AOD of above result specification the medicaments that P-gp interpose guides is able to bear or endure suffer a gender, but changeover action is not complete. The author analyses the degradation problem that its are AOD so formerly. For this, the author serves as with fat plastid Lipofectin turn gene carrier, make of AOD be able to bear or endure medical changeover action rises somewhat, clew fat plastid can serve as guide AOD target one of means to cure [3] . Be aimed at the degradation problem of AOD, the AOD of the Cucco MDRl gene that uses sulfur acting phosphoric acid to decorate undertakes MDR changeover, discovery all raises leukaemia cell to be able to bear or endure apparently in body inside and outside medical cell department is new to Changchun alkaline (the sensitivity of VCR) [4] . Because decorate hind can increase AOD of enzymatic to nucleic acid cleared action be able to bear or endure suffer a gender, and Yi Rong at water, can more effective ground and target gene undertake cross, added its changeover effect thereby [5] . The oxygen atom that additionally the author thinks to go up to nucleic acid undertakes sulfur generation is changed, methylic change or undertake with fat plastid the cell absorbs AOD lapping waiting for a method risinging while, increased cellular noxiousness on one hand, also reduced nucleic acid to turn over at the same time justice low-key effect. Get together what small element measures glycol (PEG) join is in the extreme of the 5 ′ of AOD, as a result the AOD inside indication cell is absorbed rate is apparent increase, prep above other decorates a method, and the growth that does not affect a cell is characteristic. The PEG of join of 5 ′ extreme that shows AOD is in instead justice remedial domain has wide application perspective [6] .
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